Metabolism in Cancer and Stromal Cells

8-10 SEPTEMBER 2015, Leuven, Belgium
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Metabolism in Cancer and Stromal Cells

The metabolism of cancer cells and recently also of stromal cells (endothelial cells, immune cells, fibroblasts) have emerged as critical hallmark in the (patho)physiology of organs in healthy and diseased tissue. Evidence indicates that metabolism not only co-determines the differentiation and function of cells, but it also contributes to the pathogenesis of cancer, diabetes and inflammatory diseases. With this international meeting we will focus on how cancer and stromal cells metabolically communicate and how their specific metabolism impacts disease development and progression. These insights into cellular metabolism also offer novel therapeutic opportunities for malignant, metabolic, or inflammatory disease.

This meeting will bring together researchers from cancer metabolism and stromal cell metabolism fields. Renowned speakers will provide a broad view on metabolic regulation, the link between signaling and metabolism as well as the intercellular crosstalk. This event will provide an opportunity to discuss the latest findings in those fields. These discussions will stimulate new ideas and impact the field by introducing novel concepts and experimental approaches.

This conference is organized in collaboration with Vesalius Research Center and KU Leuven.

‘Meet the Expert’ session with Dr. M. Celeste Simon
We offer all junior researchers an opportunity to join keynote speaker Dr. M. Celeste Simon in a 'Meet the Expert' session during the conference. On Thursday September 10 during the coffee break from 16:05-16:35 you will have the opportunity to ask any question/advise/feedback related to your research project/your research during an informal round table discussion. If you are interested in joining the session then send an e-mail to conferences@vib.be and let us know. Seating is very limited so make sure to reserve a spot soon!

Top speakers: 

M. Celeste Simon

University of Pennsylvania School of Medicine, US

Stefano Indraccolo

Istituto Oncologico Veneto-IRCCS, IT

Mike Murphy

MRC-Mitochondrial Biology Unit , UK

Matt Vander Heiden

Koch Institute for Integrative Cancer Research, MIT, US

Stephen Hursting

UNC School of Medicine, US

Peter Carmeliet

VIB-KU Leuven Center for Cancer Biology, BE

Jeff Rathmell

Duke University School of Medicine, US

Zolt Arany

University of Pennsylvania, US

Massimiliano Mazzone

VIB-KU Leuven Center for Cancer Biology, BE

Sarah-Maria Fendt

VIB-KU Leuven Center for Cancer Biology, BE

Michael Potente

Max Planck Institute for Heart and Lung Research, DE

Kris Olson

University of Utah, US

Nicola Zamboni

ETH Zürich, CH

Hongbo Chi

St. Jude Children's Research Hospital, US

Michael Simons

Yale University, US

Russell Jones

McGill University, CA

Karsten Hiller

University of Luxembourg, LU

Reinier Boon

Goethe-University Frankfurt am Main, DE

Gary Glick

University of Michigan, US
Download the program: 

Tuesday, 8 September, 2015

Tuesday, 8 September, 2015
13:00 - 14:15
Registration & Welcome coffee
14:15 - 17:55
Session 1: Cancer and Autoimmune Diseases
14:15 - 14:35
Welcome
14:35 - 15:35
KEYNOTE: Regulation of cell metabolism to support tumor growth
Matt Vander Heiden
Koch Institute for Integrative Cancer Research, MIT, US
Academic speaker
15:35 - 16:10
mTOR signaling in lymphocyte homeostasis and tumorigenesis
Hongbo Chi
St. Jude Children's Research Hospital, US
Academic speaker
16:10 - 16:40
Coffee Break
16:40 - 17:15
Exploiting the Metabolic Flexibility of Th17 Cells for the Treatment of Autoimmunity and Cancer
Gary Glick
University of Michigan, US
Academic speaker
17:15 - 17:35
P53 attenuates AKT signaling by modulating membrane phospholipid composition
Natalia Rueda
KU Leuven, BE
Academic speaker
17:35 - 17:55
Reprogramming GABA Metabolism towards GHB production
Marie-Pierre Junier
INSERM, FR
Academic speaker
18:30 - 20:00
Reception - Belgian Beer Tasting

Organizing Committee:

Peter Carmeliet, VIB Vesalius Research Center, KU Leuven, BE
Sarah-Maria Fendt, VIB Vesalius Research Center, KU Leuven, BE
Matt Vander Heiden, Koch Institute for Integrative Cancer Research, MIT, US
Ralph Deberardinis, The University of Texas Southwestern Medical Center, US
Evy Vierstraete, PhD, VIB Science Events Executive, BE

Wednesday, 9 September, 2015

Wednesday, 9 September, 2015
09:00 - 12:40
Session 2: Angiogenesis and Cardiovascular Diseases
09:00 - 10:00
KEYNOTE: Angiogenesis revisited: endothelial metabolism as a target?
Peter Carmeliet
VIB-KU Leuven Center for Cancer Biology, BE
Academic speaker
10:00 - 10:35
Metabolic control of lymphatic development
Michael Simons
Yale University, US
Academic speaker
10:35 - 11:05
Coffee break
11:05 - 11:40
Metabolic checkpoints during vascular growth and quiescence
Michael Potente
Max Planck Institute for Heart and Lung Research, DE
Academic speaker
11:40 - 12:15
PGC-1 and endothelial metabolism
Zolt Arany
University of Pennsylvania, US
Academic speaker
12:15 - 12:35
Regulation of endothelial metabolism by laminar shear stress
Reinier Boon
Goethe-University Frankfurt am Main, DE
Academic speaker
12:40 - 13:40
Lunch
13:40 - 15:10
Poster session 1
15:10 - 18:25
Session 3: Cancer and Mitochondrial Metabolism
15:10 - 15:45
How mitochondrial metabolism leads to ROS production
Mike Murphy
MRC-Mitochondrial Biology Unit , UK
Academic speaker
15:45 - 16:20
Tricarboxylic acid cycle metabolism in cells
Sarah-Maria Fendt
VIB-KU Leuven Center for Cancer Biology, BE
Academic speaker
16:20 - 16:50
Coffee break
16:50 - 17:25
Fatty acid metabolism in cancer cells: Are we looking at the right pathway?
Karsten Hiller
University of Luxembourg, LU
Academic speaker
17:25 - 18:00
VEGF blockade elicits a stable metabolic shift in tumor cells
Stefano Indraccolo
Istituto Oncologico Veneto-IRCCS, IT
Academic speaker
18:00 - 18:20
New insights into the mode of action of metformin through calcium flux modifications and its consequences on cancer cells mitochondria
Frederic Bost
INSERM U1065, FR
Academic speaker
19:30 - 22:30
Conference Dinner @ Faculty Club

Organizing Committee:

Peter Carmeliet, VIB Vesalius Research Center, KU Leuven, BE
Sarah-Maria Fendt, VIB Vesalius Research Center, KU Leuven, BE
Matt Vander Heiden, Koch Institute for Integrative Cancer Research, MIT, US
Ralph Deberardinis, The University of Texas Southwestern Medical Center, US
Evy Vierstraete, PhD, VIB Science Events Executive, BE

Thursday, 10 September, 2015

Thursday, 10 September, 2015
09:00 - 12:00
Session 4: Stromal Cell Metabolism
09:00 - 09:35
Influence on Vessel Shape of Macrophage Metabolism in the Tumor Hypoxic Niche
Massimiliano Mazzone
VIB-KU Leuven Center for Cancer Biology, BE
Academic speaker
09:35 - 10:10
Fueling T cell activation and anti-tumor immunity
Jeff Rathmell
Duke University School of Medicine, US
Academic speaker
10:10 - 10:40
Coffee break
10:40 - 11:15
Metabolic adaptation: implications for immunity
Russell Jones
McGill University, CA
Academic speaker
11:15 - 11:35
Role of fatty acid ß-oxidation in lymphatic development
Annalisa Zecchin
Vesalius Research Center, KU Leuven, BE
Academic speaker
11:35 - 11:55
Metabolic reprogramming of tumor-specific T cell boosts anti-tumor immunity by re-adjusting T cell metabolic fitness in the tumor microenvironment
Ping-Chih Ho
University of Lausanne, CH
Academic speaker
12:00 - 13:00
Lunch
13:00 - 14:30
Poster session 2
14:30 - 18:00
Session 5: Metabolism in Complex Diseases
14:30 - 15:30
KEYNOTE: Metabolic Adaptations in Renal Cancer
M. Celeste Simon
University of Pennsylvania School of Medicine, US
Academic speaker
15:30 - 16:05
Mitochondrial metabolism and the determination of cell fate
Kris Olson
University of Utah, US
Academic speaker
16:05 - 16:35
Coffee break
16:35 - 17:10
Obesity, Metabolism and Cancer: Mechanistic Lessons from Transdisciplinary Studies
Stephen Hursting
UNC School of Medicine, US
Academic speaker
17:10 - 17:45
Metabolism bottom-up: a haystack of needles
Nicola Zamboni
ETH Zürich, CH
Academic speaker
17:45 - 18:00
Closing remarks
Academic speaker

Organizing Committee:

Peter Carmeliet, VIB Vesalius Research Center, KU Leuven, BE
Sarah-Maria Fendt, VIB Vesalius Research Center, KU Leuven, BE
Matt Vander Heiden, Koch Institute for Integrative Cancer Research, MIT, US
Ralph Deberardinis, The University of Texas Southwestern Medical Center, US
Evy Vierstraete, PhD, VIB Science Events Executive, BE