Phase Transitions in Biology and Disease

Early Bird deadline: 31 March!
2 - 3 May 2017, Leuven, Belgium
Pictures of the event, added after the event has passed ...: 
Registration until
Friday, 21 April, 2017
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Early Bird: 
Mar 31
Final: 
Apr 21
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€ 250,00
Phd student (Final): 
€ 350,00
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VIB - PhD student (Final): 
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Academic (Final): 
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Phase Transitions in Biology and Disease
Early Bird deadline: 31 March!

In the past few years the concept of protein phase transitions has taken the field of cell biology and protein biochemistry by storm. The initial discoveries were met with great enthusiasm as they provide the rationale for the formation of membrane-less organelles, such as stress granules, processing bodies and RNP bodies, in biology and human disease. By studying the biophysics of the involved proteins, it was shown that this process could be modeled by liquid-liquid demixing, also making the connection of such liquid compartments to characteristic protein aggregations observed in numerous neurodegenerative diseases. Whereas this is perhaps one of the biggest breakthroughs in these fields in recent years, key questions remain to be addressed towards the goal of fully understanding their functional properties in the cell and targeting them in proteinopathies.

This meeting gathers leading figures from the phase transition and protein aggregation field, whose work has spearheaded the recent developments. Where have we come from? Where are we now? And moreover, which direction the field is heading? Come join us on this exciting meeting!

Top speakers: 

Simon Alberti

Max Planck Institute of Molecular Cell Biology and Genetics, DE

Clifford Brangwynne

Princeton University, US

Tanja Mittag

St. Jude Children’s Research Hospital Memphis, US

Rohit Pappu

Washington University, US

Roy Parker

University of Colorado, US

Steven McKnight

The University of Texas Southwestern Medical Center, US

Nicolas Lux Fawzi

Brown University, US

Monika Fuxreiter

University of Debrecen, HU

James Shorter

University of Pennsylvania, US

Magdalini Polymenidou

University of Zurich, CH

Peter Tompa

VIB Structural Biology Research Center, BE

Benjamin Wolozin

Boston University, US

Joost Schymkowitz

VIB-KU Leuven Center for Brain & Disease Research, BE

Frederic Rousseau

VIB-KU Leuven Center for Brain & Disease Research, BE

Paul Taylor

Howard Hughes Medical Institute, US

Day 1 - 02 May 2017

Tuesday, 2 May, 2017
11:00 - 14:00
Registration - Lunch
14:00 - 18:30
Plenary session 1 day 1
13:30 - 13:45
Welcoming Remarks
Wim Robberecht
Vice rector Biomedical Sciences KU Leuven; Head KU Leuven Lab of Neurobiology, BE
13:45 - 14:15
Structural disorder promotes phase separation of C9orf72 dipeptide repeats in ALS
Peter Tompa
VIB Structural Biology Research Center, BE
14:15 - 14:45
Disturbed phase transitions in neurological diseases
Paul Taylor
Howard Hughes Medical Institute, US
14:45 - 15:15
Visualizing structural details of disordered domain phase separation associated with ALS and cancers
Nicolas Lux Fawzi
Brown University, US
15:15 - 15:45
Phase separation of a cancer-associated ubiquitin ligase
Tanja Mittag
St. Jude Children’s Research Hospital Memphis, US
15:45 - 16:15
Coffee break
16:15 - 16:45
above
Contributions of RNA Binding Proteins to tau biology and tauopathies
Benjamin Wolozin
Boston University, US
16:45 - 17:15
Dynamic oligomerization of TDP-43 in health and disease
Magdalini Polymenidou
University of Zurich, CH
17:15 - 18:00
Moving through intracellular phase space
Clifford Brangwynne
Princeton University, US
18:00 - 19:00
Reception

Organizing Committee:

Joost Schymkowitz, Group leader, VIB-KU Leuven Center for Brain & Disease Research, BE
Frederic Rousseau, Group leader, VIB-KU Leuven Center for Brain & Disease Research, BE
Ludo Van Den Bosch, Group leader, VIB-KU Leuven Center for Brain & Disease Research, BE
Peter Tompa, Group leader, VIB-VUB Center for Structural Biology, VUB
Elke Bogaert, Post-doctoral Scientist, VIB-KU Leuven Center for Brain & Disease Research, BE
Steven Boeynaems, PhD Student, VIB-KU Leuven Center for Brain & Disease Research, BE
Lien Houbrechts, Lab coordinator, VIB-KU Leuven Center for Brain & Disease Research, BE

Day 2 - 03 May 2017

Wednesday, 3 May, 2017
09:00 - 17:15
Plenary session 1 day 2
09:00 - 09:30
RNP Granules in Health and Disease
Roy Parker
University of Colorado, US
09:30 - 10:00
RNP granules: how they form, age, and cause disease
Simon Alberti
Max Planck Institute of Molecular Cell Biology and Genetics, DE
10:00 - 10:30
A solid state conceptualization of information transfer from gene to message to protein
Steven McKnight
The University of Texas Southwestern Medical Center, US
10:30 - 11:00
Coffee break
11:00 - 11:15
Presenter selected from abstracts
11:15 - 11:30
Presenter selected from abstracts
11:30 - 11:45
Presenter selected from abstracts
11:45 - 12:00
Presenter selected from abstracts
12:00 - 14:00
Lunch + Poster session
14:00 - 17:15
Plenary session 2 day 2
14:00 - 14:30
Synthetic Functional Amyloids
Frederic Rousseau
VIB-KU Leuven Center for Brain & Disease Research, BE
14:30 - 15:00
Reversing aberrant phase transitions connected to ALS
James Shorter
University of Pennsylvania, US
15:00 - 15:15
Presenter selected from abstracts
15:15 - 15:30
Presenter selected from abstracts
15:30 - 16:00
Coffee break
16:00 - 16:30
Fuzziness in higher-order assemblies and its role in biological phase transitions
Monika Fuxreiter
University of Debrecen, HU
16:30 - 17:15
Uncovering sequence-encoded phase diagrams of intrinsically disordered proteins
Rohit Pappu
Washington University, US

Organizing Committee:

Joost Schymkowitz, Group leader, VIB-KU Leuven Center for Brain & Disease Research, BE
Frederic Rousseau, Group leader, VIB-KU Leuven Center for Brain & Disease Research, BE
Ludo Van Den Bosch, Group leader, VIB-KU Leuven Center for Brain & Disease Research, BE
Peter Tompa, Group leader, VIB-VUB Center for Structural Biology, VUB
Elke Bogaert, Post-doctoral Scientist, VIB-KU Leuven Center for Brain & Disease Research, BE
Steven Boeynaems, PhD Student, VIB-KU Leuven Center for Brain & Disease Research, BE
Lien Houbrechts, Lab coordinator, VIB-KU Leuven Center for Brain & Disease Research, BE

Hashtag: 
#PTBD17
Venue: 

The Faculty Club
Groot Begijnhof 14
3000 Leuven
Belgium

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CANCELLATION POLICY
In case you want to cancel your registration, please send a request to conferences@vib.be.
All notifications received 2 months before the start of the event, get refunded for 100% minus an administrative fee of 50 euro.
All notifications received between 1 and 2 months before the start of the event, get refunded for 50% minus an administrative fee of  50 euro.
Cancellations requests received less than 1 month before the start of the event won't be refunded.
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Public transport: 

The Faculty Club Leuven is easy to reach by public transport.
It is a 20 min walk away from the Leuven railway station.

The national railway company of Belgium is called NMBS. More info: NMBS - Belgian rail
The bus company active in Leuven is 'De Lijn': More info: De Lijn.be 

Travel by car: 

Parking 'Q-Park Leuven Heilig Hart' is located in the city center and a 5 minute walk from the venue. More information


ADDRESS:
Naamsestraat 102
3000 Leuven
Belgium

Travel by plane: 

The main airport of Belgium is located in Zaventem.
More info: Brussels airport

An alternative is Charleroi airport, located 40 minutes to the south of Brussels.
More info: Brussels South - Charleroi airport

Housing: 

La Royale
Martelarenplein 6, 3000 Leuven
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Hotel New Damshire
Schapenstraat 1, 3000 Leuven
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Novotel Leuven Centrum
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Hotel Binnenhof
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IBIS Leuven Centrum
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ParkInn by Radisson Leuven
Martelarenlaan 36, 3000 Leuven


Martin's Klooster
Onze Lieve Vrouwstraat 18, 3000 Leuven
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Theater Hotel Leuven-Centrum
Bondgenotenlaan 20, 3000 Leuven
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Contacts: 
Questions concerning the registration procedure: VIB conferences team
+32 9 244 66 11
Questions concerning: Talks - Abstracts & Program: Lien Houbrechts
+32 16 33 07 62