The Brain Mosaic: cellular heterogeneity in the CNS

22-23 September 2016, Leuven, Belgium
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The Brain Mosaic: cellular heterogeneity in the CNS

Advances in genomics through to in vivo physiology allow us, for the first time, to explore cellular heterogeneity at multiple experimental levels. Nowhere is this more important than in the Central Nervous System (CNS), where cellular heterogeneity has profound effects on all aspects of normal brain function and behavior, and explains important aspects of disease pathology.

This neuroscience meeting assembles leaders in the field of single cell analysis, together with junior faculty, post-doctoral fellows and graduate students.  We will discuss both cutting-edge technological developments in single cell analysis and what they reveal about CNS function and disease.

Meet the Expert session with: ‘Amita Sehgal - University of Pennsylvania, US’

We offer all junior researchers the opportunity to join our ‘Meet the Expert' session with Amita Sehgal. During an informal round table discussion on the 22nd of September (17:00-17:30), PhD students and postdocs will have the exclusive opportunity to ask any question/advise related to their research and careers. If you are interested in joining the session, then send an e-mail to conferences@vib.be. Seating is very limited so make sure to reserve a spot soon.

The conference will be preceded by a training day for graduate students and post-doctoral researchers, which will introduce junior researchers to essential techniques used in the field.

In addition to a great scientific and training program, there will be ample opportunities to network during the breaks, poster sessions, Meet the Expert-session and conference dinner.

Top speakers: 

Chris Walsh

Harvard Medical School, US

Chris Ponting

MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, UK

Amita Sehgal

University of Pennsylvania, US

Michael Häusser

University College London, UK

Sten Linnarsson

Karolinska Institute, SE

Ed Lein

Allen Institute for Brain Science, US

Gero Miesenböck

University of Oxford, UK

John Marioni

EMBL-EBI, UK

Guoping Fan

UCLA, US

Bassem Hassan

ICM Institute, FR & VIB Center for the Biology of Disease, KU Leuven, BE

Je Hyuk Lee

CSHL, US

Vanessa Ruta

Laboratory of Neurophysiology and Behavior, The Rockefeller University, US

Naomi Habib

Broad Institute, MIT, US

Joakim Lundeberg

SciLifeLab, SE

Michael J. McConnell

University of Virginia, US

Grant Belgard

Verge Genomics, US
Download the program: 

Day 1 - 22 September 2016

Thursday, 22 September, 2016
09:00 - 09:25
Registration & coffee
09:30 - 13:00
Session 1: The CNS one cell at a time: single cell sequencing and cell diversity
09:30 - 10:30
KEYNOTE: Molecular anatomy of the brain by large-scale single-cell RNA-seq
Sten Linnarsson
Karolinska Institute, SE
Academic speaker
10:30 - 11:00
Single Cell Analysis of Brain Somatic Mosaicism
Michael J. McConnell
University of Virginia, US
Academic speaker
11:00 - 11:30
Coffee Break
11:30 - 12:00
Dissecting heterogeneity of neuronal injury responses via Single Cell Genomics
Guoping Fan
UCLA, US
Academic speaker
12:00 - 12:30
Div-Seq: Single nucleus RNA-Seq reveals dynamics of rare adult newborn neurons
Naomi Habib
Broad Institute, MIT, US
Academic speaker
12:30 - 13:00
Genome-wide changes in lncRNA, alternative splicing and cortical patterning and shifts in the expression of marker genes, in autism
Grant Belgard
Verge Genomics, US
Academic speaker
13:00 - 13:15
Selected abstract: A molecular taxonomy of the mouse retina using single cell transcriptomics
Karthik Shekhar
Broad Institute, US
Academic speaker
13:15 - 13:20
Sponsored Talk: Merck - Taking Science Further, Faster
Irina Van der Vlies
Scientific Liaison Specialist Merck, BE
Company speaker
13:20 - 15:00
Lunch & Poster session (Odd numbers)
15:00 - 16:30
Session 2: Mapping diversity in the CNS: spatial transcriptomics
15:00 - 15:30
Single cell approaches to understanding human neocortical cell types and local circuit connectivity
Ed Lein
Allen Institute for Brain Science, US
Academic speaker
15:30 - 16:00
Positional information of gene expression in the brain cancer and development
Je Hyuk Lee
CSHL, US
Academic speaker
16:00 - 16:30
Spatially resolved gene expression heterogeneity in tissue sections
Joakim Lundeberg
SciLifeLab, SE
Academic speaker
16:30 - 17:00
Coffee Break
16:30 - 17:00
Meet the Expert: Amita Sehgal
N31

Seating for this session is limited, please send an e-mail to conferences@vib.be if you would like to attend. 

17:00 - 18:30
Session 3: New developments in technology and bioinformatics
17:00 - 17:15
Selected abstract: By any other name: quantifying neuronal subtype identity through functional meta-analysis
Megan Crow
Cold Spring Harbor Laboratory, US
Academic speaker
17:15 - 17:30
Selected Abstract: Gene regulatory network inference from single-cell RNA-seq reveals high- resolution cellular states
Sara Aibar
KU Leuven, BE
Academic speaker
17:30 - 18:00
Computational challenges in single-cell RNA-seq
John Marioni
EMBL-EBI, UK
Academic speaker
18:00 - 19:00
Reception
20:00 - 23:00
Conference Dinner @ Faculty Club

The program is elaborated by the members of the organizing committee:

Matthew Holt, VIB Center for the Biology of Disease, KU Leuven, BE
Bart De Strooper, VIB Center for the Biology of Disease, KU Leuven, BE
Chris Ponting, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, UK
Mark Fiers, VIB Center for the Biology of Disease, KU Leuven, BE
Thierry Voet, Department of Human Genetics, BE
Evy Vierstraete, Science Events Executive, BE

Day 2 - 23 September 2016

Friday, 23 September, 2016
08:30 - 09:00
Welcome Coffee
09:00 - 12:30
Session 4: CNS disease: can we explain it through sequencing?
09:00 - 10:00
KEYNOTE: Somatic mutation and genomic diversity in the human cerebral cortex
Chris Walsh
Harvard Medical School, US
Academic speaker
10:00 - 10:30
Cellular variation in brain development and disease
Bassem Hassan
ICM Institute, FR & VIB Center for the Biology of Disease, KU Leuven, BE
Academic speaker
10:30 - 11:00
Coffee Break
11:00 - 11:30
Understanding gene regulation via chromatin structure in developing human brain
Academic speaker
11:30 - 12:00
Genetics of Function and Dysfunction of the Brain
Academic speaker
12:00 - 12:15
Selected Abstract: Defining the neurovascular niche through single cell sequencing
Michael Vanlandewyck
Uppsala University / Karolinska Institute, SE
Academic speaker
12:15 - 14:00
Lunch & Poster Session (Even numbers)
14:00 - 17:15
Session 6: CNS functionality: probing activity at the single cell level
14:00 - 14:30
Genetic Dissection of Neuron and Glia Genesis using Mosaic Analysis with Double Markers (MADM)
Academic speaker
14:30 - 15:00
Neural Circuits for Adaptive Behaviors
Vanessa Ruta
Laboratory of Neurophysiology and Behavior, The Rockefeller University, US
Academic speaker
15:00 - 15:30
Optogenetics: Lighting Up the Brain
Gero Miesenböck
University of Oxford, UK
Academic speaker
15:30 - 16:00
Coffee Break
16:00 - 16:30
Circuits underlying rhythmic rest:activity behavior
Amita Sehgal
University of Pennsylvania, US
Academic speaker
16:30 - 16:45
Selected abstract: SIFamide orchestrates multiple peptidergic signals into appetitive and feeding behavior in Drosophila
Thomas Riemensperger
Department of Molecular Neurobiology of Behavior, Georg-August- Universität Göttingen. DE
Academic speaker
16:45 - 17:15
All-optical interrogation of neural circuits
Michael Häusser
University College London, UK
Academic speaker
17:15 - 17:30
Closing Remarks

The program is elaborated by the members of the organizing committee:

Matthew Holt, VIB Center for the Biology of Disease, KU Leuven, BE
Bart De Strooper, VIB Center for the Biology of Disease, KU Leuven, BE
Chris Ponting, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, UK
Mark Fiers, VIB Center for the Biology of Disease, KU Leuven, BE
Thierry Voet, Department of Human Genetics, BE
Evy Vierstraete, Science Events Executive, BE