Weizmann Institute of Science, IL

BIO

The Amit group studies the function of the Immune system in health and disease. Our main focus is to understand how gene and chromatin regulatory networks control hematopoiesis and immune response. We develop and apply state of the art high throughput genomic tools for single cell and chromatin applications to address these critical biological and therapeutic questions.

2011:  Senior Scientist: Weizmann Institute of Science                                        
Research: Genomics and Systems Biology of the Immune System.

2007-2011: Postdoctoral Fellow: Broad Institute of MIT and Harvard;
Supervisors: Prof. Regev Aviv (Broad/MIT/HHMI) and Nir Hacohen (Broad/MGH)
Research: Genomic and Systems biology approaches towards reconstructing the regulatory circuits of pathogen sensing in mammals.

2002-2007: PhD: Weizmann Institute of Science, Rehovot, Israel;
Supervisor: Prof. Yosef Yarden, Dept. of   Biological Regulation Thesis: Transcriptional and post-transcriptional constrains define the outcome of growth factor receptor signaling.


PUBLICATIONS

1. Altboum Z, Steuerman Y, David E, Barnett-Itzhaki Z, Valadarsky L, Keren-Shaul H, Meningher T, Mendelson E, Mandelboim M, Gat-Viks I, Amit I.
Digital cell quantification identifies global immune cell dynamics during influenza infection. Mol Syst Biol. 2014 Feb 28; PMID: 24586061

2. Jaitin DA, Kenigsberg E, Keren-Shaul H, Elefant N, Paul F, Zaretsky I, Mildner A, Cohen N, Jung S, Tanay A, Amit I.
Massively parallel single-cell RNA-seq for marker-free decomposition of tissues into cell types. Science. 2014 Feb 14 :776-9. PMID: 24531970

3. Cheng CS, Rai K, Garber M Hollinger A, Robbins D, Anderson S, Rosenthal A, Tzou A, Raychowdhury R, Russ C, Gershenwald JE, Lennon N, Nusbaum C, Chin L, Regev A, Amit I.
Semiconductor based DNA sequencing of histone modification states. Nature Communications. 2013 Nat Commun. 2013 Oct 25;4:2672.

4. Rais Y, Zviran A, Geula S, Gafni O, Chomsky E, Viukov S, Mansour AA, Caspi I, Krupalnik V, Zerbib M, Maza I, Mor N, Baran D, Weinberger L, Jaitin DA, Lara-Astiaso D, Blecher-Gonen R, Shipony Z, Mukamel Z, Hagai T, Gilad S, Amann-Zalcenstein D, Tanay A, Amit I, Novershtern N, Hanna JH.
Deterministic direct reprogramming of somatic cells to pluripotency. Nature. 2013 Oct 3;502(7469):65-70.

5. I Gat-Viks, N Chevrier, R Wilentzik, T Eisenhaure, R Raychowdhury, Y Steuerman, A Shalek, N Hacohen, I Amit and A Regev.
Deciphering molecular circuits from genetic variation underlying transcriptional responsiveness to stimuli. Nat Biotechnology. 2013 Apr;31(4):342-9.


MORE INFO

Ido Amit's webpage

 

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