Cancer Research UK London Research Institute / Francis Crick Institute, UK

BIO

Peter Van Loo is a group leader at the Cancer Research UK London Research Institute (starting 10/2014), due to become part of the new Francis Crick institute in 2015. As a graduate student at the University of Leuven, he developed computational approaches to detect cis-regulatory modules and to prioritise candidate disease genes. Through initial studies in breast cancer and lymphoma, he developed an interest in cancer research. After his PhD, he developed approaches to study copy-number alterations in cancer genomes, at the Institute for Cancer Research, University of Oslo. The potential created by these methods laid the foundation for many further studies in cancer genomics and prompted him to focus on massively parallel sequencing of cancers and to move to the Wellcome Trust Sanger Institute. There, he developed a strong focus on “molecular archaeology” approaches, studying the subclonal architecture of cancers and disentangling the life history of cancer genomes. His research group at the London Research Institute aims to leverage the wealth of data from massively parallel sequencing efforts to understand carcinogenesis and cancer evolution.


PUBLICATIONS

Li Y#, Schwab C#, Ryan SL#, Papaemmanuil E, Robinson HM, Jacobs P, Moorman AV, Dyer S, Borrow J, Griffiths M, Heerema NA, Carroll AJ, Talley P, Bown N, Telford N, Ross FM, Gaunt L, McNally RJ, Young BD, Sinclair P, Rand V, Teixeira MR, Joseph O, Robinson B, Maddison M, Dastugue N, Vandenberghe P, Haferlach C, Stephens PJ, Cheng J, Van Loo P, Stratton MR, Campbell PJ#, Harrison CJ#. Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia. Nature. 2014;508(7494):98-102.

Nik-Zainal S#, Van Loo P#, Wedge DC#, Alexandrov LB, Greenman CD, Lau KW, Raine K, Jones D, Marshall J, Ramakrishna M, Shlien A, Cooke SL, Hinton J, Menzies A, Stebbings LA, Leroy C, Jia M, Rance R, Mudie LJ, Gamble SJ, Stephens PJ, McLaren S, Tarpey PS, Papaemmanuil E, Davies HR, Varela I, McBride DJ, Bignell GR, Leung K, Butler AP, Teague JW, Martin S, Jönsson G, Mariani O, Boyault S, Miron P, Fatima A, Langerød A, Aparicio SA, Tutt A, Sieuwerts AM, Borg Å, Thomas G, Salomon AV, Richardson AL, Børresen-Dale AL, Futreal PA, Stratton MR, Campbell PJ; for the Breast Cancer Working Group of the International Cancer Genome Consortium. The life history of 21 breast cancers. Cell. 2012;149:994-1007.

Stephens PJ#, Tarpey PS#, Davies H, Van Loo P, Greenman C, Wedge DC, Nik-Zainal S, Martin S, Varela I, Bignell GR, Yates LR, Papaemmanuil E, Beare D, Butler A, Cheverton A, Gamble J, Hinton J, Jia M, Jayakumar A, Jones D, Latimer C, Lau KW, McLaren S, McBride DJ, Menzies A, Mudie L, Raine K, Rad R, Chapman MS, Teague J, Easton D, Langerød A; Oslo Breast Cancer Consortium (OSBREAC), Lee MT, Shen CY, Tee BT, Huimin BW, Broeks A, Vargas AC, Turashvili G, Martens J, Fatima A, Miron P, Chin SF, Thomas G, Boyault S, Mariani O, Lakhani SR, van de Vijver M, van 't Veer L, Foekens J, Desmedt C, Sotiriou C, Tutt A, Caldas C, Reis-Filho JS, Aparicio SA, Salomon AV, Børresen-Dale AL, Richardson AL, Campbell PJ, Futreal PA, Stratton MR. The landscape of cancer genes and mutational processes in breast cancer. Nature. 2012;486(7403):400-4.

Van Loo P#, Nordgard SH#, Lingjærde OC, Russnes HG, Rye IH, Sun W, Weigman VJ, Marynen P, Zetterberg A, Naume B, Perou CM, Børresen-Dale AL#, Kristensen VN#. Allele-specific copy number analysis of tumors. Proc Natl Acad Sci U S A. 2010;107(39):16910-5.

Aerts S#, Lambrechts D#, Maity S#, Van Loo P#, Coessens B#, De Smet F, Tranchevent LC, De Moor B, Marynen P, Hassan B, Carmeliet P, Moreau Y. Gene prioritization through genomic data fusion. Nat Biotechnol. 2006;24(5):537-44.

(#: equal contribution)
 

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