Possu Huang

Dr. Possu Huang is an Assistant Professor of Bioengineering at Stanford University. He received his PhD from Caltech, and subsequently did his postdoctoral research at the University of Washington before starting his own group in 2016. His research focuses on advancing the understanding of proteins to ultimately use the knowledge to engineer novel therapeutics and other protein-base nanotechnology. During his graduate studies he developed protein docking methods to first demonstrate a computationally designed protein dimer. On the basic science level, he has contributed to a large number of de novo protein designs, most notably to unlocking the design principles of the alpha/beta barrel fold. He created RosettaRemodel as part of the Rosetta modeling suite; these methods have created most of the de novo designed proteins to date. On practical application side, he created a set of HIV immunogens, called eODs, that are now being tested in human clinical trials by the International AIDS Vaccine Initiative (IAVI). His research group uses computational modeling, structural biology and experimental library optimization to continue the expansion of protein-based molecular platforms. Among the research interests are molecular motors, novel therapeutics and new protein design algorithm development.