Toshiro Sato

Dr. Sato has been engaged in basic and translational research that aims to understand how tissue stem cells self-renew in the niche microenvironment. Since the development of organoid technology, he has applied organoid technology to human tissues and have sought to understand genotype-phenotype correlations in human diseases. He has also developed a robust organoid-based platform that streamlines the study of human biology. The platform encompasses efficient establishment of organoids from patient-derived tissues, genome-editing of organoids, a high-throughput drug screening system, xenotransplantation of human organoids and co-culture systems to assess the epithelium-microbiota interactions.