The second edition of the Tumor Heterogeneity, Plasticity, and Therapy conference, held on October 3rd and 4th in the charming city of Leuven, Belgium, proved to be a resounding success. With 350 participants hailing from 23 different countries, this two-day event provided an enriching platform for scientists, researchers, and clinicians to delve into the complex world of cancer, its heterogeneity, plasticity, and evolving therapeutic approaches. The conference was brimming with scientific talks, networking opportunities, and an impressive array of over 150 poster presentations.