The long-term goals of the Artis lab are to understand the regulatory mechanisms that control immune cell homeostasis at barrier surfaces. Employing diverse models of microbial colonization, pathogen infection and chronic inflammation, we are examining how innate and adaptive immune responses are regulated in the skin, lung and intestine. I received my first RO1 in 2004, the focus of which was to interrogate the role of intestinal epithelial cells in regulating immune cell homeostasis in the intestine. I joined the faculty at UPenn in 2005 and was promoted to Professor in 2014. In 2014, I relocated to Cornell University and became the Michael Kors Professor of Immunology and founding Director of the Jill Roberts Institute for Research in IBD at Weill Cornell Medicine in New York City. We have developed a number of models to interrogate immune cell interactions with commensal and pathogenic viruses, bacteria and parasites. Our recent studies have also developed a number of translational immunology projects, including analysis of tissue samples from patients with atopic dermatitis, food allergy, obesity and IBD. I am actively involved in teaching of graduate students and MD/PhD students at Weill Cornell Medicine. Since launching my own research program, I have supervised more than 20 rotation students from multiple programs at Penn and Weill Cornell Medicine. I have been directly responsible for the training of eleven post-docs and seven full-time PhD students with the majority still in science including positions at WashU, Cincinnati Children’s, Rutgers, Cornell, University of British Columbia, University of California, Biogen and Janssen. I am currently a recipient of NIH funding and a Burroughs Wellcome Fund Award in Pathogenesis of Infectious Diseases. I have published primary papers and reviews in high profile journals including Nature, Science, Cell, Nature Immunology, Nature Medicine, Immunity, and Journal of Experimental Medicine. I have been the recipient of the Crohns and Colitis Foundation of America Young Investigator Award, the AAI Junior Faculty Award, the Lady Barbara Colyton Prize for Autoimmune Research, the Stanley Cohen Research Award, the International Cytokine Society Junior Faculty Award and the AAI-BD Investigator Award for outstanding early career contributions. These achievements demonstrate that I have a strong track record and motivation in the areas of mucosal immunology, intestinal epithelial cell biology and host-microbe interactions and that I have developed the knowledge, tools, technical expertise and leadership skills to successfully complete the proposed studies.