Dr. Pearce obtained her Ph.D. in 2005 at the University of Pennsylvania in Philadelphia, where she studied the regulation of T cell responses during infection. During her postdoctoral studies at the University of Pennsylvania, she began her research into how cellular metabolic processes govern immune responses to infection and cancer. In 2009, Dr. Pearce launched her independent research career as an Assistant Member at the Trudeau Institute in Saranac Lake, New York. In 2011, she moved to the Department of Pathology and Immunology at Washington University in St. Louis, and in 2014 was promoted to Associate Professor with tenure. In 2015, Dr. Pearce moved her group to Europe to become a Director at the Max Planck Institute for Immunobiology and Epigenetics in Freiburg, Germany. In 2018 she was awarded the Leibniz Prize for her work on immune cell metabolism. Her research continues to investigate metabolic pathways in immune cells, with a view to targeting these pathways for therapy.