Quadram Institute Bioscience, UK

BIO

Since 2008, Dr. Nathalie Juge leads a Research Team that investigates the glycobiology of host-microbe interactions in the gut. Her previous research focused on the structure-function relationships of plant and microbial glycoenzymes and their potential biotechnological application (stemming from her PhD project on barley amylases in Biochemistry-Molecular Biology of Nutrition, Marseille University, France in 1993) and successive postdoctoral positions on fungal glucoamylases at the Carlsberg Research Institute (EMBO and EU-funding) and Institute of Food Research (Marie-Curie fellowship).

After obtaining a lectureship position in Marseille University in Biochemistry and Molecular Biology (in 1997), Nathalie led a research Group on Glycosidases in Marseille (1997-1999) and in Norwich (1999-2004) while on secondment at IFR. Nathalie put together and coordinated an EU FP5 project on glycosidases and glycosidase inhibitors in food processing (1999-2003). She obtained a post-doctoral qualification “Habilitation à Diriger les Recherches” in Marseille in 2005.

Today the research team of Dr. Nathalie Juge (at Quadram Institute Bioscience, Norwich, UK) studies the molecular mechanisms of gut bacteria/mucin interactions in health and disease.

 

Key Publications

Sequeira S., Kavanaugh D., MacKenzie D. A., Šuligoj T., Walpole S., Leclaire C., Gunning A. P., Latousakis D., Willats W. G. T., Angulo J., Dong C., Juge N. Structural basis for the role of serine-rich repeat proteins from Lactobacillus reuteri in gut microbe-host interactions. Proc Natl Acad Sci USA. (2018) 115, E2706-E2715. doi: 10.1073/pnas.1715016115.

Owen C. D., Tailford L. E. , Monaco S., Šuligoj T., Vaux L., Lallement R., Khedri Z., Yu H., Lecointe K., Walshaw J., Tribolo S., Horrex M., Bell A., Chen X., Taylor G. L., Varki A., Angulo J., Juge N. Unravelling the specificity and mechanism of sialic acid recognition by the gut symbiont Ruminococcus gnavus. Nature Commun. (2017) 8, 2196. doi: 10.1038/s41467-017-02109-8.

Tailford L. E., Owen C. D., Walshaw J., Crost E. H., Hardy-Goddard J., Le Gall G., de Vos W. M., Taylor G. L., Juge N. Discovery of intramolecular trans-sialidases in human gut microbiota suggests novel mechanism of mucosal adaptation. Nat. Commun. (2015) 6, 7624.

Kober O. I., Ahl D., Pin C., Holm L., Carding S. R., Juge N. γδ T-cell-deficient mice show alterations in mucin expression, glycosylation and goblet cells but maintain an intact mucus layer. Am. J. Physiol. Gastrointest. Liver Physiol. (2014) 306, G582-93.

Speaker at
21-23 October 2018, Ghent, Belgium