University of Manchester, UK

BIO

Prof. Sabine Flitsch holds a Chair in Chemical Biology at the University of Manchester in the School of Chemistry. Her research group is housed in the Manchester Interdisciplinary Biocentre (MIB; http://www.mib.ac.uk/).

Sabine graduated from University of M√ľnster in Germany in 1982 with a first class Diploma in Chemistry. She received a Michael Wills scholarship to study for a D.Phil at the University of Oxford under the supervision of Sir Jack E. Baldwin. She then took up a DAAD Postdoctoral Fellowship at the Massachusetts Institute of Technology (MIT) to work with Professor H. Gobind Khorana until 1988 before returning to Oxford to take up a lectureship in Organic Chemistry for 6 years.

After joining the University of Edinburgh in 1995, Sabine was awarded the Zeneca Research Award in 1996 and the Glaxo Wellcome Award for Innovative Chemistry in 1997. She was also a BBSRC Research Development Fellow from 2001-4 and was recently awarded the Wolfson Merit Award by the Royal Society (2007-2012). In October 2004 Sabine moved to a Chair in Chemical Biology at the University of Manchester in the Department of Chemistry. In 2014 she was awarded the RSC Interdisciplinary Prize for her significant contributions in biological chemistry, in particular carbohydrate chemistry and glycobiology.

 

Key Publications

Craven F., Silva J., Segarra-Maset M., Huang K., Both P., Gough J., Flitsch S. L., Webb S. One-pot’ sequential enzymatic modification of synthetic glycolipids in vesicle membranes. Chem. Commun. (2018) 54, 1347-1350. DOI: 10.1039/C7CC09148F

Gray C. J., Thomas B., Upton R., Migas L. G, Eyers C. E, Barran P. E, Flitsch S. L. Applications of ion mobility mass spectrometry for high throughput, high resolution glycan analysis. Biochim. et Biophys. Acta - Gen. Subj. (2016) 1860, 1688-1709, DOI: 10.1016/J.BBAGEN.2016.02.003.

Both P., Busch H., Kelly P. P., Mutti F. G., Turner N. J.,  Flitsch S. L. Whole-Cell Biocatalysts for Stereoselective C-H Amination Reactions. J. Angewandte Chemie – International edition (2016) 55, 1511 – 1513. DOI: 10.1002/anie.201510028.

Both P.,   Green A. P.,   Gray C. J.,   Sardzik R.,   Voglmeir J.,   Fontana C.,   Austeri M.,   Rejzek M.,   Richardson D.,   Field R. A.,   Widmalm G.,   Flitsch S. L.,   Eyers C. E. Discrimination of epimeric glycans and glycopeptides using IM-MS and its potential for carbohydrate sequencing. Nature Chemistry  (2014) 6, 65-74. DOI 10.1038/NCHEM.1817.

Speaker at
21-23 October 2018, Ghent, Belgium