Dr. Ziegler graduated with honors from the University of Michigan in 1979, and in 1984 received his PhD in molecular biology from UCLA. Following post-doctoral training at the University of Washington, Dr. Ziegler spent five years as a staff scientist at Immunex, followed by three years as the Director of Immunology/Molecular Biology at Darwin Molecular. He joined the Benaroya Research Institute at Virginia Mason (BRI) as an Associate Member in 1997. He is currently Director of the Immunology Research Program and Director of Academic Affairs at BRI, and Affiliate Professor in the Immunology Department, University of Washington School of Medicine.
Dr. Ziegler’s laboratory is focused on the factors that control normal immune regulation, as well as those that contribute to disease development and progression. The laboratory is currently engaged in two areas of investigation. The first area involves the role of the transcriptional regulatory FOXP3, and FOXP3-interacting proteins, in regulatory T cell development and function. The second area involves the role of epithelial cytokines (TSLP, IL-25, and IL-33) in immune responses at mucosal surfaces. The lab has also found a novel role for TSLP in the regulation of tumor progression, and have established a program in tumor biology, including metastatic breast cancer, colitis-associated cancer and melanoma.