Uwe Sauer earned his MS and PhD in microbiology from the University of Göttingen. During his postdoc work on metabolic engineering in the chemical engineering lab of Jay Bailey in Zurich, he became interested in computational modelling of cellular behaviour and quantitative analysis of metabolic fluxes. In the late nineties, his research began to focus on quantitative understanding of interactions and regulation within complex microbial metabolic networks. For this purpose, research in the Sauer lab takes an interdisciplinary approach that combines quantitative experimentation and modelling to solve fundamental questions of how microbes coordinate their metabolism. His lab has pioneered the development of quantitative mass spectrometry-based methods for metabolomics, enabling rapid hypothesis generation on the molecular and functional operation of complex metabolic networks. The current research focus is on mapping metabolite-protein interaction networks and understanding the in vivo relevance of allosteric metabolite regulation.
Prof. Sauer has about 70 publications in peer-reviewed journals over the last 5 years, and is a member of various editorial boards, scientific steering and advisory committees of international organizations and companies in systems biology and biotechnology.
Head of Institute for Molecular Systems Biology and president of the Research Commission, ETH Zurich