Structural Dynamics in Cellular Communication (2nd edition)

20-21 SEPTEMBER 2018, BRUSSELS, BELGIUM
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Structural Dynamics in Cellular Communication (2nd edition)

After a successful first edition in February 2015, with a great audience and speakers such as Nobel Prize winner Ada Yonath, we are honored to announce a second edition of this VIB Structural Biology conference.

This meeting will feature current developments in protein science with plenary sessions focusing on:

  • macromolecular machines
  • in situ structural biology
  • structural engineering & drug discovery
  • protein function/dynamics

In addition to the scientific program, conference attendees will have ample networking opportunities during breaks, reception, conference dinner and guided walk in Brussels.

Meet the Expert session with Patrick Cramer

Especially for junior researchers a ‘Meet the Expert' session with Patrick Cramer (Director at the Max Planck Institute of Biophysical Chemistry) will be organized on the 21th of September. During an informal round table discussion PhD students and postdocs will have the exclusive opportunity to ask any question/advise related to their research and careers. If you are interested in joining the session, then send an e-mail to conferences@vib.be. Seating is limited.

BECM Satellite Meeting

On September 19, the day before the Structural Dynamics in Cellular Communication meeting, there will be a BECM satellite meeting in Brussels. 
If you would like to attend this satellite meeting for free please register separately. For more information see the program below. 

Information for poster submissions:

The format for your poster should be: A0 (841 x 1189 mm / 33.1 x 46.8 in), portrait orientation

 

Confirmed speakers

Patrick Cramer

Max Planck Institute for Biophysical Chemistry, DE

Natalie Strynadka

Department of Biochemistry, University of British Columbia, CA

Andrea Dessen

Institut de Biologie Structurale, FR

Todd O. Yeates

Department of Biochemistry, UCLA, US

Petr Leiman

University of Texas Medical Branch, US

Andrew Carter

MRC Lab of Molecular Biology, Cambridge, UK

Georgios Skiniotis

Molecular and Cellular Physiology Department, Stanford University, US

Gabrielle Rudenko

Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, US

Zachary A. Wood

Department of Biochemistry and Molecular Biology, University of Georgia, US

Martin Blackledge

Institut de Biologie Structurale, FR

John C. H. Spence

Department of Physics, Arizona State University, US

Paul M W French

Physics Department, Imperial College London, UK

Martin Pilhofer

Department of Biology, Institute of Molecular Biology & Biophysics, ETH Zurich, CH

Han Remaut

VIB-VUB Center for Structural Biology, BE

Jan Steyaert

VIB-VUB Center for Structural Biology, BE

BECM Satellite Meeting

Wednesday, 19 September, 2018

This event day precedes the Structural Dynamics in Cellular Communication meeting on 20-21 September 2018 in Brussels, BE.

If you would like to attend this satellite meeting please register seperately, for free, via this link: Register for BECM Satellite Meeting

BECM Satellite Meeting

Address: Auditorium  QD, building D, VUB, Pleinlaan 2, 1050, Brussels

09:30 - 09:45
Introduction to BECM
Rouslan Efremov
VIB-VUB Center for Structural Biology, BE
09:45 - 10:15
Introduction of JEOL cryoARM300 - JEOL
10:15 - 10:45
cryoARM300 at BECM - VIB-VUB
10:45 - 11:00
Coffee break
11:00 - 11:30
Analysis of conformational variability in cryo-EM
Pawel Penczek
The University of Texas, McGavern Medical School, US
11:30 - 12:00
Assembly, injection, translocation: Using cryoEM to unterstand the mechanism of bacterial ABC toxins
Christos Gatsogiannis
Max Planck Institute of Molecular Physiology, DE
12:00 - 12:30
Fibril Structure of Abeta(1-42) by Cryo-EM
Gunnar Schroeder
Computational Structural Biology, Forschungszentrum Jülich, DE
12:30 - 13:30
Sandwich lunch
13:30 - 14:00
Cryo-EM with phase plates
Radostin Danev
University of Tokyo, JP
14:00 - 14:30
Determining and approaching some of the physical limits in electron cryomicroscopy
14:30 - 15:00
Microfluidic EM sample preparation for differential visual proteomics and diagnostics
Thomas Braun
Center for Cellular Imaging and Nanoanalytics (C-CINA), Biozentrum, University of Basel (CH)
15:00 - 15:15
Coffee break
Official opening of the VIB-VUB facility for Bio Electron Cryogenic Microscopy (BECM)

Address: Auditorium  QC, building Q, VUB, Pleinlaan 2, 1050, Brussels

16:00 - 16:05
Welcome
Jan Steyaert
VIB-VUB Center for Structural Biology, BE
16:05 - 16:35
BECM Inaugural Lecture
16:35 - 16:40
Jo Bury
Managing Director VIB, BE
16:40 - 16:45
Caroline Pauwels
Rector VUB, BE
16:45 - 16:50
Philippe Muyters
Flemish Minister for Work, Economy, Innovation and Sport
16:50 - 16:55
Hans Willems
Secretary General, FWO, BE
16:55 - 16:57
Acknowledgements
Rouslan Efremov
VIB-VUB Center for Structural Biology, BE
17:00 - 17:15
Ribbon cutting ceremony @ BECM facility
17:15
Reception with barbecue outside the BECM facility + VUB restaurant

Day 1 - 20 September 2018

Thursday, 20 September, 2018
08:45 - 09:10
Registration & welcome coffee
09:10 - 09:15
Welcome by the Organizing Committee
Session 1: Macromolecular Machines
09:15 - 09:50
Structural hybrid methods to probe the Type III Secretion injectisome of pathogenic bacteria
Natalie Strynadka
Department of Biochemistry, University of British Columbia, CA
Academic speaker
09:50 - 10:25
Biophysics of bacteriophage tail contraction
Petr Leiman
University of Texas Medical Branch, US
Academic speaker
10:25 - 10:55
Coffee break
10:55 - 11:30
Transporting cargo over long distances: insights from dynein/dynactin structures
Andrew Carter
MRC Lab of Molecular Biology, Cambridge, UK
Academic speaker
11:30 - 12:05
Molecular architecture of a core bacterial cell wall synthesis complex
Andrea Dessen
Institut de Biologie Structurale, FR
Academic speaker
12:05 - 12:20
Selected talk 1: Cryo-EM structures of the mitochondrial calcium uniporters
Rozbeh Baradaran
MSKCC, US
12:20 - 12:35
Selected talk 2: Structural insights into the human Mediator Tail module
Vincent Villeret
CNRS, FR
12:35 - 13:30
Lunch
13:30 - 14:30
Poster session - odd numbers
Session 2: Protein Function/Dynamics
14:30 - 15:05
CryoEM visualization of G protein-coupled receptors
Georgios Skiniotis
Molecular and Cellular Physiology Department, Stanford University, US
Academic speaker
15:05 - 15:40
How nature harnesses entropy to tune protein function
Zachary A. Wood
Department of Biochemistry and Molecular Biology, University of Georgia, US
Academic speaker
15:40 - 16:10
Coffee break
16:10 - 16:45
Complex Dynamics and Dynamic Complexes: NMR Studies of Large Scale Dynamics and their role in Protein Function
Martin Blackledge
Institut de Biologie Structurale, FR
Academic speaker
16:45 - 17:20
From Nanobodies to Megabodies for applications in cryo-EM
Jan Steyaert
VIB-VUB Center for Structural Biology, BE
Academic speaker
17:20 - 17:35
Selected talk 3: Conformational dynamics of a secondary multidrug transporter with single-molecule FRET
Aurélie Roth
Université libre de Bruxelles, BE
17:35 - 17:50
Selected talk 4: Structural basis of quiescence and activation of the translocase motor SecA: A paradigm for the allosteric regulation of molecular motors
Srinath Krishnamurthy
Rega Institute, KU Leuven, BE
17:50 - 19:00
Reception
20:00 - 22:30
Conference dinner

Organizing Committee:

Han Remaut, VIB-VUB Center for Structural Biology, BE
Jan Steyaert, VIB-VUB Center for Structural Biology, BE
Peter Tompa, VIB-VUB Center for Structural Biology, BE
Joris messens, VIB-VUB Center for Structural Biology, BE
Savvas Savvides, VIB-UGent Center for Inflammation Research, BE
Wim Hol, Department of Biochemistry, University of Washington, BE
Evy Vierstraete, PhD, VIB Science Events Manager

Day 2 - 21 September 2018

Friday, 21 September, 2018
08:45 - 09:15
Welcome coffee
Session 3: in situ Structural Biology
09:15 - 09:50
Integrated structural biology reveals the basis of gene transcription
Patrick Cramer
Max Planck Institute for Biophysical Chemistry, DE
Academic speaker
09:50 - 10:25
Cell-cell interactions mediated by bacterial contractile injection systems
Martin Pilhofer
Department of Biology, Institute of Molecular Biology & Biophysics, ETH Zurich, CH
Academic speaker
10:25 - 10:55
Coffee break
10:25 - 10:55
Meet the Expert session
Patrick Cramer
Max Planck Institute for Biophysical Chemistry, DE
10:55 - 11:30
Imaging protein dynamics by X-ray laser
John C. H. Spence
Department of Physics, Arizona State University, US
Academic speaker
11:30 - 12:05
Fluorescence lifetime imaging and Förster resonant energy transfer
Paul M W French
Physics Department, Imperial College London, UK
Academic speaker
12:05 - 12:35
Selected talk 5: Cell engineering to implement live-cell structural biology: reconstruction of the exocytic machinery
Oriol Gallego
Department of Experimental and Health Sciences, University Pompeu Fabra (UPF), ES
12:20 - 12:35
Selected Talk 6: The architecture of EGFR’s basal complexes reveals autoinhibition mechanisms in dimers and oligomers
Marisa Martin-Fernandez
Science & Technology Facilities Council, UK
12:35 - 13:30
Lunch
13:30 - 14:30
Poster session - even numbers
Session 4: Structural Engineering & Drug Discovery
14:30 - 15:05
Dynamic Control of Synaptic Organizers – Shaping protein interaction networks in the synaptic cleft
Gabrielle Rudenko
Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, US
Academic speaker
15:05 - 15:40
Giant protein assemblies in nature and by design
Todd O. Yeates
Department of Biochemistry, UCLA, US
Academic speaker
15:40 - 16:10
Coffee break
16:10 - 16:45
Structure and therapeutic targeting of bacterial S-layers
Han Remaut
VIB-VUB Center for Structural Biology, BE
Academic speaker
16:45 - 17:00
Selected talk 7: Structural activation of pro-inflammatory humancytokine IL-23 by cognate IL-23 receptor enables recruitment of the shared receptor IL-12Rb1
Yehudi Bloch
VIB-UGent Center for Inflammation Research, BE
17:00 - 17:15
Selected talk 8: The structural basis of nanobody unfolding reversibility and thermoresistance
Patrick Kunz
German Cancer Research Center (DKFZ), Heidelberg, DE
17:15 - 17:30
Selected Talk 9: Fragment-based and Computational Methods Identify Ligandable Pockets on the von Hippel-Lindau E3 Ubiquitin Ligase
Inge Van Molle
VIB Laboratory of Structural and Molecular Microbiology, VUB, BE
17:30 - 17:40
Closing remarks

Organizing Committee:

Han Remaut, VIB-VUB Center for Structural Biology, BE
Jan Steyaert, VIB-VUB Center for Structural Biology, BE
Peter Tompa, VIB-VUB Center for Structural Biology, BE
Joris messens, VIB-VUB Center for Structural Biology, BE
Savvas Savvides, VIB-UGent Center for Inflammation Research, BE
Wim Hol, Department of Biochemistry, University of Washington, BE
Evy Vierstraete, PhD, VIB Science Events Manager

Attendees

The full list of attendees will be available on 13-09-2018 until 04-10-2018.
This list will only be available for registered attendees of the event.

Abstracts

The full list of abstracts will be available on 13-09-2018 until 04-10-2018.
Only registered attendees can download abstracts.