Following my masters in Chemistry at the University of Leiden and the University of Virginia, Charlottesville, USA, I did my PhD in Immunology at the LUMC, Dept. IHB (HLA-DR3/ Peptide/ T cell Interactions) and worked at Cytel Corporation, San Diego, USA. I received postdoctoral training at the Mayo Clinic, Rochester, MN, USA and was acknowledged a 5-year fellowship by the Royal Dutch Academy of Sciences during which period I focused on the immunology of leprosy and tuberculosis, particularly the identification of HLA-restricted T cell (epitopes) that are essential to protective immunity or immunopathology and biomarkers for development of immunodiagnostics.
My current research focusses on Immunodiagnostics of Leprosy including basic-, translational-, applied- as well as field research and Tuberculosis Vaccine Development using HLA transgenic mouse models. Currently, I am a member of the steering committee of the IDEAL consortium (Initiative for Diagnostic and Epidemiological Assays for Leprosy) and have designed and coordinated several large-scale, multi-center studies in e.g. Bangladesh, Brazil, Ethiopia and Nepal.