Hansruedi Mathys is a postdoctoral associate in the laboratory of Li-Huei Tsai at the Picower Institute for Learning and Memory at MIT. He studied Biology at the University of Bern, Switzerland and received a Ph.D. degree in Biochemistry from the University of Basel, Switzerland. During his PhD, working under the supervision of Witek Filipowicz at the Friedrich Miescher Institute, he has made important contributions to our understanding of miRNA-mediated gene silencing. Dr. Mathys’ current research focuses on understanding the molecular mechanisms underlying Alzheimer’s disease (AD). Dr. Mathys is using single-nucleus RNA-sequencing of postmortem brain tissue to determine how gene expression is disrupted in AD in specific neuronal and glial cell types and subtypes, across different brain regions, and at different stages of disease progression.